Vector-borne infectious diseases

Time-resolved proteomic profile of Amblyomma americanum tick saliva during feeding

This study identifies tick saliva proteins injected during feeding using LC-MS/MS, finding 284 conserved proteins that may serve as vaccine targets.

Tick-borne pathogens in ticks (Acari: Ixodidae) collected from various domestic and wild hosts in Corsica (France), a Mediterranean island environment

The study screens tick-borne pathogens in ticks from Corsica, finding DNA of 11 previously unreported species in 48% of tick pools.

Measurement of organ-specific and acute-phase blood protein levels in early Lyme disease

The paper identifies 10 blood proteins with altered serum levels in early Lyme disease patients, developing a 10-protein panel for potential diagnostic use.

Ticks Home in on Body Heat: A New Understanding of Ectoparasite Host-Seeking and Repellent Action

This study shows ticks use radiant heat sensed by their Hallers organ to find hosts and demonstrates repellents disrupt this heat sensing without affecting odor-based host-seeking.

Knockout of Babesia bovis rad51 ortholog and its complementation by expression from the BbACc3 artificial chromosome platform

This paper knocks out the Bbrad51 gene in Babesia bovis and shows that an artificial chromosome platform can complement the loss of function, though it may cause recombination with native chromosomes.

Novel tumor suppressor roles for GZMA and RASGRP1 in dissemination of both Theileria annulata-transformed macrophages and human B-lymphoma cells

The paper identifies GZMA and RASGRP1 as tumor suppressors in Theileria-transformed bovine macrophages and human B-lymphoma cells through transcriptomic and functional analyses.

Borrelia burgdorferi 297 bmpA encode the mRNA that contains ORF for a leader peptide that regulates bmpA gene expression.

The paper identifies a leader peptide in BmpA mRNA that regulates gene expression in Borrelia species through specific ribosome binding sites.

Whole body transcriptomes and new insights into the biology of the tick Ixodes ricinus

The paper analyzes the whole-body transcriptome of Ixodes ricinus ticks to study gene expression changes during feeding and compares genetic variation between wild and lab strains.

Whole genome sequence and comparative analysis of Borrelia burgdorferi MM1

The paper presents the complete genome sequence of Borrelia burgdorferi MM1 strain, identifies it as a new sequence type, and provides the first contiguous assembly of a specific plasmid.

Learning and Mapping Lyme Disease Patient Trajectories from Electronic Medical Data for Stratification of Disease Risk and Therapeutic Response

The paper uses machine learning on electronic medical records to identify comorbidities and medications associated with Lyme disease and its treatment outcomes.