SPIN90 modulates the architecture of lamellipodial actin in an ARPC5L dependent fashion.
Luyan Cao, Angika Basant, Miroslav Mladenov, Naoko Kogata, Antoine G. Jegou, Guillaume Romet‐Lemonne, Sophie Brasselet, Manos Mavrakis, Michael Way
SPIN90 selectively activates ArpC5L-containing Arp2/3 complexes to make linear actin filaments, shaping lamellipodial filament orientation and protrusion efficiency in B16 melanoma cells.
bioRxiv · Oct 3, 2026 · PreprintCell Biology✦ In-depth digest