Naoko Kogata

SPIN90 modulates the architecture of lamellipodial actin in an ARPC5L dependent fashion.

SPIN90 selectively activates ArpC5L-containing Arp2/3 complexes to make linear actin filaments, shaping lamellipodial filament orientation and protrusion efficiency in B16 melanoma cells.

The actomyosin cortex controls t-tubule remodeling in muscle

This study identifies the actomyosin cortex, regulated by Arpc5, as critical for t-tubule remodeling in muscle, linking it to muscle function and disorders.

Myofibers drive postnatal myonuclear accretion through Arp2/3-dependent membrane protrusions

This study shows that myofibers use Arp2/3-dependent membrane protrusions to drive myoblast fusion and myonuclear accretion during postnatal muscle growth.

Branched actin networks mediate macrophage-dependent host microbiota homeostasis.

This study shows that Arpc5-containing Arp2/3 complexes are critical for macrophage function and maintaining host-microbiota homeostasis, as their loss leads to intestinal inflammation.