Sophie Brasselet

SPIN90 modulates the architecture of lamellipodial actin in an ARPC5L dependent fashion.

SPIN90 selectively activates ArpC5L-containing Arp2/3 complexes to make linear actin filaments, shaping lamellipodial filament orientation and protrusion efficiency in B16 melanoma cells.

Nanoscale rheological heterogeneity revealed by Single Particle orientation Tracking (SPoT) of ultrashort carbon nanotubes in brain tissue

This paper introduces SPoT, a method to track carbon nanotubes in brain tissue to study nanoscale rheological heterogeneity by analyzing translational and rotational dynamics.

SMOLM-LFM: ratiometric single molecule orientation without polarizers

This paper introduces SMOLM-LFM, a method for 3D single-molecule orientation and localization microscopy using ratiometric intensity estimation without polarization projections, enabling 6D molecular analysis.

Polarization MultiFocus Microscopy for volumetric super-resolution and orientation imaging of biofilaments

This paper introduces PolMFM, a method for simultaneous 3D localization and orientation imaging of single molecules, validated on actin filaments and chromatin in crickets.

4polar3D : Single molecule 3D orientation imaging of dense actin networks using ratiometric polarization splitting

The paper introduces 4polar3D, a method for 3D orientation imaging of dense actin networks using ratiometric polarization splitting, demonstrating its ability to resolve nanoscale organization in cellular structures.

Genetically encoded reporters of actin filament organization in living cells and tissues

This paper develops genetically encoded fluorescent reporters to quantify actin filament organization in living cells and tissues using fluorescence polarization microscopy.

Lipid order degradation in autoimmune demyelination probed by polarization resolved coherent Raman microscopy

This paper quantifies lipid order degradation in myelin during autoimmune demyelination using polarization-resolved coherent Raman microscopy.