Manos Mavrakis

SPIN90 modulates the architecture of lamellipodial actin in an ARPC5L dependent fashion.

SPIN90 selectively activates ArpC5L-containing Arp2/3 complexes to make linear actin filaments, shaping lamellipodial filament orientation and protrusion efficiency in B16 melanoma cells.

Quantitative biophysical analysis of human septin hexamer and octamer self-assembly on model membranes

This study quantitatively compares the membrane binding and self-assembly of human septin hexamers and octamers using biophysical methods, revealing distinct structural properties and functional implications.

Spatiotemporal localization and activity of mitochondria regulate actomyosin contractility in Drosophila gastrulation

This study shows that mitochondrial redistribution and activity are crucial for apical constriction in Drosophila gastrulation, regulated by the Dorsal signaling pathway.

4polar3D : Single molecule 3D orientation imaging of dense actin networks using ratiometric polarization splitting

The paper introduces 4polar3D, a method for 3D orientation imaging of dense actin networks using ratiometric polarization splitting, demonstrating its ability to resolve nanoscale organization in cellular structures.

Genetically encoded reporters of actin filament organization in living cells and tissues

This paper develops genetically encoded fluorescent reporters to quantify actin filament organization in living cells and tissues using fluorescence polarization microscopy.