Topic · Cancer Research · Biochemistry, Genetics and Molecular Biology
OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.
68 papers
Matthew A. Spence, Matthew D Mortimer, Ashley M. Buckle, Bùi Quang Minh, Colin J. Jackson
This study constructs a comprehensive phylogeny of 6000 serpin sequences across all kingdoms of life, showing convergent evolution rather than horizontal gene transfer for the central hub proteins.
Molecular Biology and Evolution · Mar 18, 2021Peer-reviewedBioinformatics
Kazuya Tsumagari, Chih‐Hsiang Chang, Yasushi Ishihama
The paper identifies cleavage sites of ectodomain shedding in 10 human cell lines using mass spectrometry and finds 411 cleavage sites on 132 membrane proteins.
iScience · Mar 2, 2021Peer-reviewedMolecular Biology
Jessie L. Gan, Cheryl Eisen, Vaughn V. Smider
The paper identifies potential antibody epitopes in MMP-15 using bioinformatics tools, highlighting conserved and divergent regions for therapeutic targeting.
bioRxiv · Dec 21, 2020 · PreprintMolecular Biology
Ayaka Imanishi, Yuma Aoki, Masaki Kakehi, Shunsuke Mori, Tomomi Takano, Yukihiko Kubota, Hon‐Song Kim, Yukimasa Shibata, Kiyoji Nishiwaki
The paper investigates genetic interactions between ADAMTS proteases and basement membrane proteins in C. elegans gonad development, identifying suppressor mutations that affect both mig-17 and gon-1 mutants.
PLoS ONE · Dec 2, 2020Peer-reviewedDevelopmental Biology
Camila Audrey dos Reis, José Rosa Gomes
This study examines MMP-2 and MMP-9 expression in rat small intestine mucosa during intrauterine and postnatal development, finding no expression in epithelium but MMP-9 in mast cells postnatally.
bioRxiv · Apr 26, 2019 · PreprintDevelopmental Biology
Cyril Andrieu, Audrey Montigny, Dominique Alfandari, Eric Théveneau
This study shows MMP14's basolateral localization drives apicobasal polarity changes during EMT independently of its catalytic activity in chick neural crest cells.
bioRxiv · Aug 28, 2018 · PreprintDevelopmental Biology
Ivo J. H. M. de Vos, Evelyn Yaqiong Tao, Sheena L. M. Ong, Julian Goggi, Thomas S. Scerri, Gabrielle R.A. Wilson, Chernis Guai Mun Low, Arnette Shi Wei Wong, Dominic Grussu, Alexander P.A. Stegmann, Michel van Geel, Renske Janssen, David J. Amor, Melanie Bahlo, Norris Ray Dunn, , Maurice A. M. Van Steensel
The paper identifies a hypomorphic MMP14 mutation in Winchester syndrome and shows its catalytic activity determines disease severity using in vitro and zebrafish models.
Human Molecular Genetics · May 3, 2018Peer-reviewedGenetics
Vishnu Hosur, Michelle L. Farley, Lisa M. Burzenski, Leonard D. Shultz, Michael V. Wiles
The paper shows ADAM17 is the main enzyme that removes the outer part of the AREG protein, which is important for skin health and cancer.
FEBS Open Bio · Feb 23, 2018Peer-reviewedGenetics