Vaughn V. Smider

This study immunized cows with HIV Env trimers to generate broadly neutralizing antibodies targeting the V2-apex, revealing ultralong CDRH3 antibodies outcompete shorter ones in the response.

This study investigates whether engineering HIV Env trimers or using gp120 can induce broadly neutralizing antibodies in cows, finding that trimers are more effective than monomeric gp120.

The paper analyzes ACE2 diversity across species and its interaction with SARS-CoV-2 RBD, finding bovine ACE2 has lower binding affinity compared to human ACE2.

The paper identifies potential antibody epitopes in MMP-15 using bioinformatics tools, highlighting conserved and divergent regions for therapeutic targeting.

The paper evaluates synthetic gene optimization by testing codon-optimized genes in an antibiotic selection system and finds they do not enhance resistance, indicating other factors are more important.