Research on Leishmaniasis Studies

SILAC-based quantitative proteomics reveals pleiotropic, phenotypic modulation in primary murine macrophages infected with the protozoan pathogen Leishmania donovani

This study uses SILAC-based proteomics to identify 86 differentially expressed proteins in murine macrophages infected with Leishmania donovani, revealing changes in host metabolism and lysosomal organization.

A genome-wide association study highlights a regulatory role for IFNG-AS1 contributing to cutaneous leishmaniasis in Brazil

This study conducts a genome-wide association study to identify genetic risk factors for cutaneous leishmaniasis in Brazil, finding novel associations and highlighting the regulatory role of IFNG-AS1 in interferon-gamma responses.

Meta-taxonomic Analysis of Prokaryotic and Eukaryotic Gut Flora in Stool Samples from Visceral Leishmaniasis Cases and Endemic Controls in Bihar State India

The paper uses meta-taxonomic analysis of gut flora in VL cases and controls to identify microbial associations with disease status and diversity.

Transcriptional Blood Signatures for Active and Amphotericin B Treated Visceral Leishmaniasis in India

This paper identifies transcriptional signatures in whole blood associated with asymptomatic Leishmania donovani infection, active visceral leishmaniasis, and treatment outcomes with different amphotericin B regimens.

The mRNA-bound proteome of Leishmania mexicana: novel genetic insight into an ancient parasite

This study identifies 1,400 mRNA binding proteins in Leishmania mexicana across three lifecycle stages, revealing stage-specific RNA binding and limited correlation between mRNA levels and protein expression.

Population Structure of Leishmania using POPSICLE reveals extensive dichotomy in zygosity and discloses the role of sex in diversity of the parasite

The paper upgrades POPSICLE for aneuploid genomes to study Leishmania population structure, revealing dichotomous zygosities and the role of sex in genetic diversity.

Leishmania naiffi and Leishmania guyanensis reference genomes highlight genome structure and gene evolution in the Viannia subgenus

This paper assembles and annotates reference genomes for Leishmania naiffi and Leishmania guyanensis, revealing genomic traits and evolutionary patterns in the Viannia subgenus.

Prediction of the secundary structure at the tRNASer (UCN) of Lutzomyia longipalpis (Diptera: Psychodidae)

The paper predicts the secondary structure of tRNASer (UCN) in Lutzomyia longipalpis as a molecular marker for species identification.