Mandy J Sanders

Evolutionary genomics of a zoonotic parasite across the Neotropical Realm

The paper analyzes the genomic diversity of Leishmania (Viannia) braziliensis across the Neotropical Realm, identifying two major parasite groups associated with different biomes and highlighting ecological and epidemiological differences.

Long-read assembly and comparative evidence-based reanalysis of Cryptosporidium genome sequences reveal new biological insights

The paper presents a new high-quality genome assembly and annotation for Cryptosporidium parvum IOWA, revealing structural and functional insights into its genome and evolutionary relationships with related species.

Daily rhythms in the transcriptomes of the human parasite Schistosoma mansoni

This study identifies daily transcriptomic rhythms in Schistosoma mansoni, revealing rhythmic gene expression patterns and their potential relevance to parasite survival and drug targets.

Ecological divergence and hybridization of Neotropical Leishmania parasites

This study examines the evolutionary history and hybridization of Leishmania parasites using whole genome sequencing, revealing ecological divergence and genetic mosaic ancestry in hybrids.

Large CRISPR-Cas-induced deletions in the oxamniquine resistance locus of the human parasite Schistosoma mansoni

This study uses CRISPR-Cas9 to induce deletions in the SULT-OR gene of Schistosoma mansoni, showing potential for oxamniquine resistance but limited mRNA knockdown due to low mutation frequency.

Genomic analysis of natural intra-specific hybrids among Ethiopian isolates of Leishmania donovani

The paper analyzes whole-genome sequences of Leishmania donovani isolates from Ethiopia to investigate hybridization patterns and recombination in natural populations.

Global genome diversity of the Leishmania donovani complex

The paper presents a comprehensive genome-wide study of Leishmania donovani complex isolates, revealing genetic diversity and structural variation across species and geographical regions.

Leishmania naiffi and Leishmania guyanensis reference genomes highlight genome structure and gene evolution in the Viannia subgenus

This paper assembles and annotates reference genomes for Leishmania naiffi and Leishmania guyanensis, revealing genomic traits and evolutionary patterns in the Viannia subgenus.

Complete avian malaria parasite genomes reveal features associated with lineage specific evolution in birds and mammals

The paper reports the genome sequencing of two avian malaria parasites and identifies lineage-specific features associated with their evolution in birds and mammals.

Single-cell transcriptomics of malaria parasites

This study applies single-cell RNA-sequencing to malaria parasites, revealing transcriptional variation and novel gene expression patterns in sexual stages.