Damarys Loew

This study identifies L-CK1.2 interacting partners in Leishmania and host macrophages, revealing its dual role in parasite survival and host immune processes.

This paper develops a method to isolate cell-type-specific extracellular vesicles from infarcted mouse hearts and demonstrates their functional properties.

The paper identifies and characterizes two novel Plasmodium vivax merozoite proteins, PvMP45 and PvMP36, which bind reticulocyte receptors and are targets of protective antibodies, suggesting their potential as vaccine candidates.

This study shows that translational control of 53BP1 mRNA regulates adaptive mutability in melanoma cells, and targeting eIF4A reduces resistance to BRAF/MEK inhibitors.

This study shows that acetyl-CoA synthetase (ACAS) in Plasmodium falciparum is essential for nuclear histone acetylation, which regulates gene expression and the transcriptional cycle during the parasite's life cycle.

This study identifies a catalytically inactive PKCα mutation that drives chordoid glioma by rewiring cellular interactions and impairing cell junction function.

The paper determines the cryo-EM structure of the holocentric CCAN from Bombyx mori, revealing a self-contained dimer that forms a point-centromere-like architecture and incorporates novel Centromeric Subunit proteins.

This study identifies CD133 as a regulator of EV cargo and angiogenic function in BL-TNBC, showing its role in shaping EV composition and promoting tumor angiogenesis.

This study identifies how Leishmania donovani hijacks host ferritin to create an iron reservoir, protecting against oxidative stress and ferroptosis.

This paper identifies syntabulin as a determinant of chemosensitivity in high-grade serous ovarian cancer by linking mitochondrial metabolism and mitotic fidelity.

This paper introduces a hydrodynamic method to produce extracellular vesicles from stem cell spheroids, showing increased yield and distinct protein cargo profiles under hydrodynamic stimulation.

The paper examines chromatin regulation in brown algae, showing loss of canonical silencing systems and emergence of H3K79 methylation as a repressive mechanism.

This study identifies ORF1p interactions with proteins and chromatin in neurons, showing its role in gene regulation and neurite morphology.

This study identifies CARM1-mediated methylation of ALIX as critical for its interactions with SH3-domain proteins during cytokinesis.

The paper identifies glutamate methylation as a novel histone modification in diatoms and other organisms, showing structural effects on nucleosome stability.

This study identifies a metabolism-chromatin axis that regulates ribosome heterogeneity in Plasmodium falciparum during host-to-vector transmission.

The paper identifies a shared persistence program in triple-negative breast cancer across treatments and patients, revealing key drivers and mechanisms of drug resistance.

This study harmonizes quality controls across proteomics core facilities to improve data comparability and reliability through a 4-year longitudinal dataset and common processing software.

The paper identifies CTNND2 as an SRGAP2 effector that regulates synaptic maturation and links human evolution to synaptic neoteny.

This study shows mechanical stress increases EV release from cancer cells via caveolin-1, leading to more tumorigenic EVs that promote metastasis.

The paper identifies Ku-binding motifs in RAG2, XLF, PAXX, and MRI that mediate their interactions with Ku and support functional redundancy during V(D)J recombination.

The paper investigates LINE-1 ORF1p protein and RNA expression in mouse and human brains, finding increased levels with aging and neuron-specific expression patterns.

This paper shows that the Legionella pneumophila effector LegK1 suppresses RNA silencing by interacting with Argonaute proteins and activating NF-κB signaling, enhancing bacterial virulence.

This study identifies RACK1 as a repressor of KIR4.1 translation in astrocytes, showing its role in regulating neuronal activity through modulation of KIR4.1 expression.

This study shows microglial TNFα regulates brain phosphorylation during sleep, affecting sleep need and duration through synaptic proteins.

This study identifies OTX2's roles in adult choroid plexus function through knockdown models and proteomic analysis, revealing its impact on secretion, immune responses, and RNA processing.

The paper shows that CSR-1 slicer activity and codon usage regulate 22G-RNA biogenesis in C. elegans germline mRNAs.

The paper shows that the Pif1 helicase is inhibited by the Mer3-MutLβ complex during meiotic recombination, limiting gene conversion tract length.

The paper identifies 47 histone PTMs in the brown alga Ectocarpus, including a novel mark, and shows their stable patterns through the life cycle and association with gene expression.

The paper identifies the role of the MutLγ-Exo1 complex in meiotic crossover formation by showing Exo1 recruits Cdc5 to activate MutLγ and highlights its spatial regulation near DSB hotspots.