Pascale Pescher

The paper uses a five-layer systems analysis to show that protein degradation, not genomic changes, drives stage differentiation in Leishmania parasites.

This study compares macrophage biology between hamsters and mice to identify factors contributing to differential susceptibility to L. donovani infection.

The paper generates a hybrid between Leishmania infantum and Leishmania tarentolae, showing genomic compatibility and transcriptomic differences driven by gene copy number and mRNA turnover.

The paper shows genome instability in Leishmania enables fitness gain through epistatic gene copy number variations and compensatory post-transcriptional mechanisms.

This study uses SILAC-based proteomics to identify 86 differentially expressed proteins in murine macrophages infected with Leishmania donovani, revealing changes in host metabolism and lysosomal organization.