Neonatal and fetal brain pathology

This paper reviews preclinical studies on umbilical cord blood cell therapy for perinatal brain injury, finding greater efficacy in intraventricular hemorrhage models, mesenchymal stromal cells, and local administration routes.

This study shows that deleting miR-155 in myeloid cells reduces seizure severity and inflammation in a neonatal hypoxia-induced seizures model.

This study uses single-nucleus RNA-seq to show that chorioamnionitis disrupts cerebellar cell maturation in preterm nonhuman primates, leading to Purkinje cell loss and altered granule and oligodendrocyte development.

This study shows that tactile stimulation and FGF-2 administration after perinatal cortical injury in rats promote functional recovery by altering neuronal morphology and FGF-2 expression.

This study establishes a new neonatal rat model for hypoxia ischemia reperfusion brain damage by using a CCA muscle bridge method, showing effective ischemia reperfusion and brain damage.

This study compares EEG connectivity in full-term and preterm infants during their first year, finding age-related trends and differences between groups.

This paper uses a graph convolutional neural network to predict brain age in preterm neonates, showing it outperforms other methods and links brain age to future neurodevelopmental outcomes.

This study investigates the effects of carnosine pretreatment on inflammation and the PI3K/Akt pathway in neonatal rats after hypoxia-ischemia, finding reduced inflammation and increased Akt activation.