Neonatal and fetal brain pathology

Cerebral hemodynamics and cytochrome c oxidase in hypoxic-ischemic rabbit fetuses

The paper measures cerebral hemodynamics and cytochrome c oxidase in hypoxic-ischemic rabbit fetuses and finds a distinct response pattern compared to newborns.

Selective vulnerability of intracortical projection neurons drives long-term cortical circuit rewiring after perinatal hypoxia

This study shows that perinatal hypoxia leads to persistent transcriptional and structural changes in cortical neurons, resulting in altered connectivity and behavioral deficits in adult mice.

Age-Adjusted Cerebellar Volumetry and Developmental Outcomes in Extremely Low Birth Weight Infants

This study examines cerebellar volume in extremely low birth weight infants and finds that age-adjusted volumetric patterns correlate with developmental outcomes.

Combined lactate and hypothermia therapy enhances neuroprotection following neonatal hypoxic-ischemic brain injury

This study shows that combining lactate with hypothermia improves neuroprotection in neonatal hypoxic-ischemic brain injury by enhancing lesion recovery and reducing neuroinflammation and apoptosis.

Cross-omics profiling reveals cortical neuronal dysfunction following neonatal intraventricular haemorrhage that is attenuated by decorin treatment

This study uses cross-omics analysis in a neonatal mouse model of IVH to identify cortical neuronal dysfunction and shows decorin treatment reduces injury by targeting ferroptosis and enhancing microglial phagocytosis.

Aberrant Pain Phenotypes Emerge Following Prenatal Hypoxic-Ischemic Injury in a Rabbit Model of Cerebral Palsy

This study shows that prenatal hypoxia-ischemia in rabbits leads to altered sensory development, allodynia, anxiety-like behavior, and changes in nociceptive afferent distribution.

Mitochondrial Optic Atrophy (OPA)1 expression regulates the injury response to neonatal hypoxia-ischaemia.

This study shows that OPA1 expression affects mitochondrial function and DNA content in neonatal hypoxia-ischaemia, with OPA1 loss leading to mitochondrial fragmentation and increased brain injury.

Perinatal ischemic stroke impairs motor and cognitive development, muscle structure, and gut microbiota composition, with functional improvement following fecal microbiota transplantation in a mouse model

This study shows that perinatal ischemic stroke affects motor skills, cognitive abilities, muscle structure, and gut microbiota in mice, with improved motor function after fecal microbiota transplantation.

Persistent sensory processing and behavioral atypicalities in a mouse model of neonatal encephalopathy

This study examines the long-term effects of neonatal hypoxia-ischemia injury in mice, finding behavioral and neural changes linked to impulsive-like behavior in adulthood.

Mild perinatal hypoxia uncouples excitatory-inhibitory circuit maturation and reprograms neocortical organization

This study investigates the effects of mild perinatal hypoxia on cortical development in rats, finding disrupted excitatory-inhibitory circuit maturation and increased vulnerability in specific brain regions.

Deep learning based behavioral analysis in a neonatal rat model of hypoxic ischemic brain injury

The paper develops an automated behavioral analysis framework using DeepLabCut for neonatal HI rat models, showing strong agreement with manual scoring.

Complement modulation synergizes with therapeutic hypothermia in a rat model of neonatal HIE

This study shows that combining complement modulation with therapeutic hypothermia improves outcomes in a rat model of neonatal HIE, with sex-specific effects.

Early Blood Metabolome Remodeling Reveals Metabolic Signatures of Hypoxic-Ischemic Encephalopathy

This paper identifies metabolic signatures of hypoxic-ischemic encephalopathy (HIE) using blood-based metabolomics and machine learning, revealing early metabolic shifts that distinguish HIE from non-HIE neonates.

Novel neonatal hypoxic-ischemic model demonstrates neuroinflammation-associated memory deficits without neuronal loss

This paper introduces a novel rodent model of neonatal global cerebral ischemia using cardiac arrest and cardiopulmonary resuscitation, showing memory deficits without neuronal loss.

Environmental co-option of chromatin potential links prenatal hypoxia to persistent cortical circuit dysfunction

The paper investigates how transient prenatal hypoxia affects chromatin accessibility and transcriptional responses in mouse cortical neurons, linking these changes to long-term circuit dysfunction.

Low-frequency transcranial magnetic stimulation offers both immediate and delayed neuroprotection in neonatal hypoxia-ischemia model

This study shows that low-frequency transcranial magnetic stimulation reduces brain injury in a neonatal hypoxia-ischemia model by modulating glutamatergic transmission and providing both immediate and delayed neuroprotection.

Lactate receptor, HCAR1, in neonatal hypoxic-ischemic encephalopathy

This study examines HCAR1 expression and function in neonatal brains, finding that HCAR1 modulates neuronal excitability and that its absence worsens hypoxic-ischemic seizures.

Prematurity Insults Remodel Cerebellar Development and Behavior

This study models prematurity-associated insults in mice to show how different insults and their sequence alter cerebellar development and lead to distinct behavioral outcomes.

Comparative Analysis of Neonatal Hypomyelination Models Using Spatial Transcriptomics

This study compares the effects of intermittent hypoxia and hypoxia-ischemia models on myelination in neonatal mice using spatial transcriptomics, finding region-specific differences in oligodendrocyte populations and inflammatory responses.

Quieting the Storm: Hypoxia as a Strategy to Boost UC-MSC Therapies for Neonatal Hypoxic-Ischemic Encephalopathy

This study compares prolonged mild hypoxia and short severe hypoxia preconditioning of UC-MSCs for neonatal HIE treatment, finding that short severe hypoxia improves functional recovery and alters proteomic pathways related to neural repair.

Nose-to-Brain Healing: Hypoxia-Preconditioned Mesenchymal Stem Cells Prompt Recovery in Hypoxic-Ischemic Encephalopathy Rats

This study shows that intranasal administration of hypoxia-preconditioned mesenchymal stem cells or their secretome improves recovery in neonatal HIE rats, even at low doses.

Physioxia-modulated mesenchymal stem cells secretome has higher capacity to preserve neuronal network and translation processes in hypoxic-ischemic encephalopathy in vitro model

This study shows that physioxia-modulated UC-MSC secretome better preserves neuronal network and translation processes in an in vitro HIE model than traditional UC-MSCs.

Intranasal therapies for neonatal hypoxic-ischemic encephalopathy: Systematic review, synthesis, and implications for global accessibility to care

This paper reviews intranasal therapies for neonatal hypoxic-ischemic encephalopathy, highlighting their potential for global accessibility due to low cost and ease of administration.

Mild neonatal hypoxia disrupts adult hippocampal learning and memory and is associated with CK2-mediated dysregulation of synaptic calcium-activated potassium channel KCNN2

This study shows that mild neonatal hypoxia causes long-term hippocampal learning and memory deficits in mice through CK2-mediated dysregulation of KCNN2 channels, independent of white matter injury.

Dihydromyricetin alleviated the damage of hypoxia-induced mouse neurons by reducing ROS levels and inhibiting the expression of PAR and gammaH2AX

This study shows dihydromyricetin reduces ROS and PAR/gammaH2AX in hypoxia-treated neurons, protecting against hypoxic-ischemic encephalopathy.

Perinatal Brain Injury Triggers Niche-Specific Changes to Cellular Biogeography

This study maps the regenerative response to newborn brain injury in mice using spatial transcriptomics, revealing niche-specific changes in cell states, composition, and spatial organization.

Mice born preterm develop gait dystonia and reduced cortical parvalbumin immunoreactivity

This study develops a mouse model of preterm birth to investigate its link to dystonia and finds reduced cortical parvalbumin immunoreactivity in preterm mice.

Microglial depletion worsens lesion in female but not male C57BL/6J mice after P10 hypoxia-ischemia

This study shows that microglial depletion worsens hypoxia-ischemia injury in female but not male mice, suggesting sex-dependent roles of microglia in brain injury.

Multiscale entropy analysis of combined EEG-fNIRS measurement in preterm neonates

This study uses multiscale entropy analysis on EEG-fNIRS data from preterm neonates to assess brain maturation, finding increased EEG MSE and decreased fNIRS MSE with gestational age.

Silencing neuroinflammatory reactive astrocyte activating factors ameliorates disease outcomes in perinatal white matter injury

This study shows that reducing C3-expressing reactive astrocytes in a mouse model of perinatal white matter injury improves myelination and behavioral outcomes, and identifies these cells as potential therapeutic targets in human WMI.