Author

Jonathan Smith

Royal College of Surgeons in IrelandORCID 0000-0002-8069-2128Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Claire E. McCoyiD· 1 shared Cristina Ruedell ReschkeiD· 1 shared David Clifford HenshalliD· 1 shared Davis Leitner· 1 shared Delphi Morris· 1 shared Devika DahiyaiD· 1 shared Dhanya K. NambiariD· 1 shared Forrest Bowling· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperNeuroscience

Claire E. McCoyORCID

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2 papers

Recent·Most cited

Alphavirus replicon particle expressing IL-12 reprograms tumor-associated macrophages and neutrophils and induces anti-tumor immunity

Momoko Ishikawa, Dhanya K. Nambiar, Jaya Sastri, Forrest Bowling, Keiko Ishimoto, Fumiya Tao, Koyo Takahashi, Ivan Stephanek, Hongbin Cao, Davis Leitner, Kenta Matsuda, Fred M. Baik, John B. Sunwoo, Quynh‐Thu Le, Jonathan Smith, Wataru Akahata

This study uses an alphavirus replicon particle expressing IL-12 to reprogram immunosuppressive tumor-associated macrophages and neutrophils, enhancing anti-tumor immunity and reducing tumor growth in mouse models.

bioRxiv · Aug 7, 2025 · PreprintCancer Biology

A role for myeloid miR-155 in regulating hypoxia induced seizures in neonatal C57BL/J6 mice

Devika Dahiya, Jonathan Smith, Tammy Strickland, Delphi Morris, Cristina Ruedell Reschke, Tobías Engel, David Clifford Henshall, Claire E. McCoy, Jennifer K. Dowling

This study shows that deleting miR-155 in myeloid cells reduces seizure severity and inflammation in a neonatal hypoxia-induced seizures model.

bioRxiv · Sep 22, 2022 · PreprintNeuroscience