Clostridium difficile and Clostridium perfringens research

This paper uses MinHash to rapidly approximate genomic distances and predict ribotypes in Clostridioides difficile genomes, reducing computational demands for transmission analysis.

The paper develops regulatory, metabolic, and integrated models for C. difficile to understand its colonization mechanisms and interactions with the gut microbiota.

This study shows that species richness in synthetic human gut communities determines the outcome of C. difficile invasion, with mechanisms like acidification and resource competition playing key roles.

The paper identifies novel genetic islands in Clostridiodes difficile RT106 strains and links them to emergent phenotypes contributing to their dominance.

This study shows that Spo0A regulates the sin locus in C. difficile, controlling sporulation, toxin production, and motility by binding to its upstream region.

This study uses whole genome sequencing to analyze C. difficile isolates and identifies multiple introductions and transmission events in a healthcare network, highlighting genetic variability and antimicrobial resistance.

This study examines how bacterial composition and function change over a year after fecal microbiota transplantation in immunocompromised patients, finding limited long-term donor strain persistence and complex functional shifts.