Selva Rupa Christinal Immanuel

The paper shows adenylyl cyclase agonists inhibit Mtb growth by rerouting carbon to virulence lipids through ETC blockade and cAMP-driven metabolic remodeling.

The paper develops regulatory, metabolic, and integrated models for C. difficile to understand its colonization mechanisms and interactions with the gut microbiota.

This paper introduces PRIME, a model predicting environment-specific vulnerabilities in Mtb's regulatory and metabolic networks, validated through genome-wide fitness screens.

This study shows that disrupting the ArcA regulatory network in TetR E. coli increases tetracycline susceptibility, suggesting a strategy to re-sensitize AMR pathogens.