Serdar Turkarslan

This study shows that host oxidative stress primes Mycobacterium tuberculosis for rapid antibiotic resistance evolution by creating permissive genomic backgrounds that accelerate resistance mutations.

The paper investigates heat-induced alternative splicing changes in the coral Acropora cervicornis under different thermal stress conditions and finds that 40% of genes undergo alternative splicing, with intron retention dominating responses.

This study identifies pathway partitioning as a mechanism for complete denitrification in microbial communities and shows how imbalances in substrate utilization can disrupt cooperativity and lead to nitrous oxide emissions.

The paper shows how gene regulatory network topology in glioma stem-like cells influences drug resistance and treatment escape, suggesting strategies to overcome resistance through combinatorial therapies.

This study integrates omics data to reveal post-transcriptional regulation mechanisms in Halobacterium salinarum NRC-1, showing 54% of genes are regulated by multiple mechanisms and 7% show conditional regulation.

The paper develops a metadata schema based on Schema.org to improve the findability of infectious disease datasets and computational tools across repositories.

The paper uses single-cell analysis of GBM patient samples and xenografts to identify regulatory networks driving treatment-induced tumor evolution and proposes a framework for precision medicine.

The paper develops regulatory, metabolic, and integrated models for C. difficile to understand its colonization mechanisms and interactions with the gut microbiota.

The paper identifies 141 genetic programs in multiple myeloma that predict disease outcomes and reveal mechanisms of relapse and therapy response.

This study identifies MtrA as a critical regulator of peptidoglycan cleavage in Mtb, essential for survival under acidic stress and a potential drug target.