Venomous Animal Envenomation and Studies

Venomics and Peptidomics of Palearctic vipers: Clade-wide analysis of seven taxa of the genera Vipera, Montivipera, Macrovipera and Daboia across Türkiye

This study analyzes venom composition across seven Turkish viper taxa using proteomics and peptidomics, identifying new toxin sequences and comparing them to other Palearctic vipers to improve snakebite risk assessment.

De novo genome assembly and annotation of the saw-scaled viper Echis carinatus, a medically important venomous snake in the Indian Subcontinent

The paper assembles and annotates the genome of Echis carinatus, identifying toxin-coding genes and providing a resource for venom research.

A robust genome and assembly with transcriptomic data from the striped scorpion, Centruroides vittatus.

The paper presents a high-quality genome assembly and transcriptomic data for the striped scorpion, Centruroides vittatus, identifying venom toxin genes and expression differences between venom gland and body tissue.

Molecular Dynamics studies of Long Neurotoxins against nAChR provide key insights towards design of therapeutic peptides for Dyskinesia

The paper designs peptides targeting nAChR using molecular docking and dynamics to develop therapeutic options for Dyskinesia, showing a novel peptide has better binding affinity than a full toxin.

Domain loss enabled evolution of novel functions in a gene superfamily

The paper reconstructs the evolutionary history of three-finger toxins (3FTxs) and identifies their non-toxin ancestor as a non-secretory Ly6 in squamate reptiles.

ALOHA: AI-guided tool for the quantification of venom-induced haemorrhage in mice

ALOHA is an AI-guided tool that quantifies venom-induced haemorrhage in mice using smartphone imaging, reducing analysis time and human error.

Validation of a colorimetric LAMP to detect Loxosceles experimental envenomation

This paper validates a colorimetric LAMP assay for detecting Loxosceles envenomation, showing high sensitivity and specificity compared to PCR.

Specificity of Loxosceles α clade phospholipase D enzymes for choline-containing lipids: role of a conserved aromatic cage

The paper investigates the role of an aromatic cage in the lipid specificity of Loxosceles α clade phospholipase D enzymes using molecular dynamics simulations and experimental validation.

ScrepYard: an online resource for disulfide-stabilised tandem repeat peptides

ScrepYard is an online resource for identifying and characterizing SCREP sequences, revealing structural features of multivalent peptides and demonstrating its utility in virtual screening.

In vitro discovery and optimization of a human monoclonal antibody that neutralizes neurotoxicity and lethality of cobra snake venom

A recombinant human monoclonal antibody was optimized to neutralize whole cobra venom in mice, preventing lethality by targeting neurotoxins.

GENETIC BASES OF APOSEMATIC TRAITS: INSIGHTS FROM THE SKIN TRANSCRIPTIONAL PROFILES OF Oophaga POISON FROGS

The paper characterizes the skin transcriptomic profiles of Oophaga poison frogs to understand the genetic basis of their aposematic traits and chemical defenses.

Genome sequencing and neurotoxin diversity of a wandering spider Pardosa pseudoannulata (pond wolf spider)

The paper reports the genome sequence of the wandering spider Pardosa pseudoannulata and analyzes genes related to silk and venom toxin production, revealing insights into its neurotoxin selectivity and potential pest control role.

Gene content of the fish-hunting cone snail Conus consors

The paper analyzes transcriptomic and genomic data from Conus consors to identify protein sequences and conopeptides.

VenomKB v2.0: A knowledge repository for computational toxinology

VenomKB v2.0 is an open-access resource for venom bioactivities, sequences, and classifications, providing tools for computational toxinology and drug discovery.

Comparative analyses of toxin-associated gene homologs from an Old World viper, Daboia russelii.

The paper compares toxin-associated gene homologs in Daboia russelii using whole-genome sequencing data from skin exuviate, identifying unique sequence motifs and structural residues across venom domains.