Topic · Dermatology · Medicine
OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.
7 papers
Tolga Düz, Tobias Rolka, Dániel Törőcsik, Hendrik Reuter, Benjamin Al, Stefan Gallinat, Jan Baumbach, Nicholas Holzscheck
The paper investigates the molecular mechanisms of comedogenesis in human acne using single-cell transcriptomics, identifying a microcomedone-like cell population and supporting the comedone switch hypothesis.
bioRxiv · Oct 7, 2026 · PreprintBioinformatics
Ann Don Low, Omkar Kulkarni, François Brillet, Eganathan Kaliyamoorthy, Angeline Su Ling Tay, Scott Rice, Viduthalai Rasheedkhan Regina, Tarun Chopra
This study identifies propionate, a short-chain fatty acid from Cutibacterium acnes, as a driver of lipogenesis and holocrine secretion in human sebocytes.
bioRxiv · Sep 24, 2026 · PreprintMolecular Biology
Yang Chen, Britta De Pessemier, Tyler D. Myers, Simone Zuffa, Jasmine Zemlin, Sayeh Pourhamidi, Susi Elaine Dal Belo, Anthony C. Woo, Magali Moreau, Jolanta Idkowiak‐Baldys, Iveta Kalcheva, Paulo Wender Portal Gomes, Chloe Lieng, Samia Almoughrabie, Anna Dan Nguyen, , Rob D. Knight
This study identifies distinct microbial and metabolic features in non-lesional acne skin using multi-omics analyses, showing molecular dysbiosis extends beyond visible lesions.
npj Biofilms and Microbiomes · Aug 6, 2026Peer-reviewedMicrobiology
Takashi Sugihira, Masakazu Tamai, Kohei Takagi, Barbora Salcman, Tetsuro Kobayashi, Alison J. Hobro, Seitaro Nakagawa, Yukiko Takeuchi, Eri Ishikawa, Motoko Maekawa, Yuji Owada, Naohiro Inohara, Hiroki Takahashi, Nicholas Isaac Smith, Sho Yamasaki, , Yuumi Nakamura
This study identifies C16:0 as a lipid driver of acne through Lrig1+ follicular progenitor cells, independent of microbes.
bioRxiv · Aug 30, 2025 · PreprintCell Biology
Md Shafiuddin, Wen-chi Huang, Gabriel William Prather, Jeffrey Ryan Anton, Andrew Lawrence Martin, Sydney B. Sillart, Jonathan Z. Tang, Michael R. Vittori, Michael J. Prinsen, Jessica Jane Ninneman, Chandrashekhara Manithody, Jeffrey P. Henderson, Alexander W. Aleem, Ma. Xenia G. Ilagan, William H. McCoy
This study characterizes RoxP, a Cutibacterium protein essential for skin colonization and infection, and develops a sensitive ELISA to detect it in human biofluids.
Journal of Investigative Dermatology · May 26, 2025Peer-reviewedMicrobiology
Zhaohui Du, Tejaswi Iyyanki, Samuel Lessard, Michael J. Chao, FinnGen, Christian Asbrand, Dany Nassar, Katherine Wood Klinger, Emanuele de Rinaldis, Khader Shameer, Clément Chatelain
This study conducts a GWAS to analyze acne severity, identifying two new loci and six novel genes associated with severity, while showing limited overlap with known acne risk loci.
medRxiv · Nov 13, 2023 · PreprintGenetic & Genomic Medicine
Jacob B. Hall, Aparna A. Divaraniya, Hao-Chih Lee, Christine Becker, Benjamin D. McCauley, Patricia K. Glowe, Robert Sebra, Ana Brânduşa Pavel, Giselle Singer, Amanda M. Nelson, Diane M. Thiboutot, Ellen S. Marmur, Eric E. Schadt, Joshua Zeichner, Emma Guttman‐Yassky, , Joel T. Dudley
This study performs a multi-omic analysis of acne patients and non-acne individuals to identify molecular subnetworks associated with disease status.
bioRxiv · Mar 28, 2019 · PreprintSystems Biology