NF-κB Signaling Pathways

Immune differentiation regulator p100 tunes NF-κB responses to TNF

The paper reveals that p100 modulates NF-κB responses to TNF by enabling a late RelB:p50 activity that alters gene expression programs.

Variation in Genome-wide NF-kappaB RELA Binding Sites upon Microbial Stimuli and Identification of a Virus Response Profile

The paper identifies stimulus-specific RELA binding sites in human cells and shows their association with antiviral gene regulation and IRF motifs.

A Novel function for Cactus/IκB inhibitor to promote Toll signals in the Drosophila embryo

The paper shows that Cactus promotes Toll signals in Drosophila embryos by modulating Dorsal nuclear localization, revealing differential behavior of the Dorsal gradient in response to Cactus concentrations.