Overventilation-induced airspace acidification increases susceptibility to Pseudomonas pneumonia
Matthias Felten, Chunjiang Tan, Sebastian Ferencik, J. Li, Eleftheria Letsiou, Jasmin Lienau, Holger Müller-Redetzky, Andreas Christian Hocke, Theresa C. Firsching, Achim D. Gruber, Gopinath Krishnamoorthy, Matthias Ochs, Christina Brandenberger, Qi Zhang, Wolfgang Michael Kuebler, Martin Witzenrath
This study shows that high tidal volume ventilation acidifies alveolar lining fluid, increasing susceptibility to Pseudomonas pneumonia by reducing NHE1 expression.
ERJ Open Research · Jun 25, 2026Peer-reviewedImmunology