A second-sphere threonine residue directs iron-oxygen species in a Fe(II)/α-ketoglutarate-dependent isonitrile synthase
Naike Ye, Antonio Del Rio Flores, David W. Kastner, Kelsey R. Miller-Brown, Heather J. Kulik, Wenjun Zhang, Catherine Luschinsky Drennan
The paper identifies a second-sphere threonine residue that directs iron-oxygen species in an Fe(II)/α-ketoglutarate-dependent isonitrile synthase, revealing its role in catalytic regulation.
bioRxiv · Oct 30, 2026 · PreprintBiochemistry