Legionella and Acanthamoeba research

This study expands the Legionellaceae family by identifying new species and highlights the need for taxonomic restructuring based on genomic and clinical data.

The paper identifies four Acanthamoeba cyst wall proteins and a mannose-binding domain as diagnostic targets for detecting cysts and trophozoites in eye infections.

This study shows that three Fis proteins in L. pneumophila regulate virulence genes through distinct and cooperative mechanisms, rather than as redundant backups.

The paper identifies 63 ART-like proteins in 41 Legionella species, organized into 39 families, including 26 novel ones, and proposes a database for further study.

This paper identifies and characterizes cyst wall proteins of Acanthamoeba, showing their localization patterns, structural origins, and diagnostic potential through molecular and structural analyses.

This study identifies Hmg20a and Nol9 as host factors restricting L. pneumophila replication by repressing Rab7, which is co-opted by the bacterium via SulF to facilitate phagosome biogenesis.

The paper analyzes the genome of Legionella pneumophila ST901 to identify genetic features contributing to its virulence and endemicity in northern Italy.

This paper shows that the Legionella pneumophila effector LegK1 suppresses RNA silencing by interacting with Argonaute proteins and activating NF-κB signaling, enhancing bacterial virulence.

The paper identifies 59 compounds that inhibit Balamuthia mandrillaris growth and reconstructs its transcriptome to determine potential molecular targets for drug development.

This study identifies quassinoid compounds that bind to cell division proteins in Neigleria fowleri, suggesting they could inhibit growth and proliferation of the pathogen.