Isabelle Q. Phan

This paper introduces a multi-agent LLM system to automate and optimize protein purification protocols, improving efficiency and accuracy in protocol creation.

This paper shows that enolase inhibitors, specifically HEX, are effective against Naegleria fowleri by inhibiting its glycolytic pathway and extending survival in infected rodents.

The paper reports the structural determination of 19 N. fowleri proteins, identifying potential drug targets with structural differences from human homologs.

The paper identifies JBP3, a J-binding protein in Leishmania, which associates with complexes involved in transcription termination and chromatin remodeling, enabling polycistronic transcription and post-transcriptional regulation.

The paper predicts SARS-CoV-2 B-cell epitopes using computational methods and validates them with ELISA, finding two antigens with high sensitivity and specificity for serological diagnosis of COVID-19.

The paper identifies 59 compounds that inhibit Balamuthia mandrillaris growth and reconstructs its transcriptome to determine potential molecular targets for drug development.