Peter John Myler

The paper analyzes Gardnerella prophages and their endolysins, finding clustering of prophage sequences by bacterial species within the genus.

This paper reports the purification, crystallization, and structure of Trichomonas vaginalis pyrophosphate-dependent phosphofructokinase (TvPPi-PFK), revealing its active site and additional ligand-binding sites.

This paper introduces a multi-agent LLM system to automate and optimize protein purification protocols, improving efficiency and accuracy in protocol creation.

The paper reports high-resolution structures of T. cruzi glycolytic enzymes and identifies potential inhibitors through structural analysis and virtual screening.

The paper benchmarks five Hi-C scaffolders on four reference genomes, finding HiRise and Lachesis perform best across various conditions.

Edison evaluates scaffolding accuracy using edit distance, showing it is more reliable than N50 for assessing genome assembly quality.

The paper shows genome instability in Leishmania enables fitness gain through epistatic gene copy number variations and compensatory post-transcriptional mechanisms.

The paper reports the structural determination of 19 N. fowleri proteins, identifying potential drug targets with structural differences from human homologs.

The paper identifies JBP3, a J-binding protein in Leishmania, which associates with complexes involved in transcription termination and chromatin remodeling, enabling polycistronic transcription and post-transcriptional regulation.

The paper predicts SARS-CoV-2 B-cell epitopes using computational methods and validates them with ELISA, finding two antigens with high sensitivity and specificity for serological diagnosis of COVID-19.

The paper identifies 59 compounds that inhibit Balamuthia mandrillaris growth and reconstructs its transcriptome to determine potential molecular targets for drug development.