An evolutionary-conserved Wnt3/β-catenin/Sp5 feedback loop restricts head organizer activity in Hydra
Matthias Christian Vogg, Leonardo L Beccari, Laura Iglesias Ollé…·Brigitte Galliot
The paper identifies Sp5 as a novel inhibitor of the Wnt/β-catenin signaling pathway in Hydra, revealing an evolutionary-conserved feedback loop that restricts head organizer activity.