Brigitte Galliot

The paper investigates differential regulation of the Wnt/β-catenin/TCF/Sp5/Zic4 network in Hydra's epidermis and gastrodermis, revealing distinct roles in head organizer activity.

The paper shows that asymmetrical ROS metabolism in Hydra leads to distinct injury-induced ROS signaling in apical and basal regenerating tips, driving different regenerative responses.

The paper shows Zic4 silencing induces transdifferentiation in Hydra and identifies a Wnt-controlled GRN that regulates cell fate and cell cycle re-entry.

The paper compares apical and basal regeneration in Hydra, identifying gene modulations and signaling pathways involved in regeneration.

The paper identifies Sp5 as a novel inhibitor of the Wnt/β-catenin signaling pathway in Hydra, revealing an evolutionary-conserved feedback loop that restricts head organizer activity.

This study identifies autophagy deficiency as a driver of aging in Hydra, showing that Rapamycin delays aging through phagocytosis rather than autophagy flux.

This paper reviews mechanisms by which Hydra vulgaris resists aging through stem cell maintenance, contrasting with Hydra oligactis that rapidly ages under stress.