Leonardo L Beccari

The paper shows Zic4 silencing induces transdifferentiation in Hydra and identifies a Wnt-controlled GRN that regulates cell fate and cell cycle re-entry.

The paper uses in-cis mutations to study CTCF site functions in the mouse HoxD cluster, showing their roles in insulation, enhancer-promoter interactions, and TAD border formation.

The paper compares Hoxd gene regulation in mammalian vibrissae and avian feather primordia with trunk elongation in mice and chickens, showing lineage-specific enhancer usage and functional divergence in conserved CREs.

The paper identifies HOX13-mediated regulation of DBX2 in limb development and shows enhancers can cross TAD boundaries to regulate genes in different domains.

The paper investigates how chromatin topology affects the timing of enhancer function at the HoxD locus, finding that enhancer sequences can overcome adverse chromatin architecture to activate genes.

The paper identifies Sp5 as a novel inhibitor of the Wnt/β-catenin signaling pathway in Hydra, revealing an evolutionary-conserved feedback loop that restricts head organizer activity.

The paper compares bimodal HoxD gene regulation in chicken and mouse limb development, finding conserved mechanisms with species-specific differences in enhancer activity and TAD boundaries.

The paper investigates the HoxD cluster's role as a dynamic TAD boundary in limb development, showing its resilience and ability to maintain regulatory segregation.

The paper investigates how genomic rearrangements affect TAD structures at the HoxD locus by analyzing long-range chromatin interactions and boundary selection mechanisms.