Michael J. Layden

This study analyzes gene expression changes after Latrunculin B-induced actin depolymerization, revealing extensive transcriptional effects on cytoskeletal and non-cytoskeletal genes.

The paper uses single-cell RNA sequencing to show that distinct neuronal subtypes in cnidarians emerge at different developmental stages, revealing temporal patterning in neurogenesis.

This study shows that in Nematostella vectensis, nervous system ablation leads to ectopic head regeneration in head fragments, suggesting the nervous system provides positional information to suppress head regeneration in foot fragments.

This paper demonstrates that the RALA peptide effectively delivers CRISPR components in DNA, RNA, and RNP formats to primary mesenchymal stem cells with high viability and low cytotoxicity.

The paper identifies conserved and lineage-specific gene regulatory programs involved in cnidocyte specification in Nematostella vectensis, revealing how novel transcription factors contribute to cnidocyte diversification.

The paper tracks neuronal subtype responses in Nematostella during growth, degrowth, and regeneration, finding that neuronal numbers scale with body size and regenerates show subtype-specific changes.

This study investigates the evolution of acetylcholine signaling in Nematostella vectensis, showing neurotransmitter activity predates cnidarian-bilaterian divergence and muscle activation evolved later.

The paper systematically characterizes NvLWamide-like neurons in Nematostella, revealing stereotypy in nerve net development and consistent neural subtype patterns.