Adrenal Hormones and Disorders

IFNG-producing self-reactive CD4+ T cells drive autoimmune adrenalitis in a mouse model of Addison's disease

This study establishes a mouse model of Experimental Autoimmune Adrenalitis (EAA) and identifies IFNG-producing CD4+ T cells as key drivers of autoimmune adrenalitis.

Adrenal rather than central dysfunction limits HPA axis recovery after chronic glucocorticoid treatment in male mice

This study identifies the adrenal as the primary site limiting HPA axis recovery after chronic glucocorticoid treatment in male mice, showing adrenocortical cell loss and steroidogenesis defects.

Single-exon deletions of ZNRF3 exon 2 cause congenital adrenal hypoplasia

The paper identifies single-exon deletions in ZNRF3 exon 2 as a cause of congenital adrenal hypoplasia by disrupting Wnt/β-catenin signaling.