Ales Drobek

The paper shows that prior antigen exposure redirects CD8 T-cell activation programs, shaping progeny fate and persistence through distinct stemness and effector programs in naive and memory cells.

This study establishes a mouse model of Experimental Autoimmune Adrenalitis (EAA) and identifies IFNG-producing CD4+ T cells as key drivers of autoimmune adrenalitis.

This study shows that TANK and AZI2 prevent excessive inflammation by limiting Treg expansion and RIPK1-mediated cell death.

This study shows that enhanced RNAi in mice does not improve antiviral immunity in vivo, but may work in vitro under specific conditions.

This study identifies ABIN1 as a negative regulator of effector functions in cytotoxic T cells, showing its role in suppressing NF-κB and p38 pathways.

This study investigates immune and hematopoietic system alterations in Bardet-Biedl Syndrome patients and a mouse model, finding increased autoimmune disease incidence, elevated white blood cell counts, and B cell abnormalities.