Aleš Neuwirth

This study establishes a mouse model of Experimental Autoimmune Adrenalitis (EAA) and identifies IFNG-producing CD4+ T cells as key drivers of autoimmune adrenalitis.

The paper identifies reduced effector and cytotoxic T-cell gene expression in early type 1 diabetes across multiple T-cell subsets using single-cell transcriptomics and flow cytometry.

This study shows HIF1α is crucial for steroid hormone production in adrenal cells, with its absence increasing steroid levels and overexpression reducing them, affecting systemic health.