Chemotherapy-induced organ toxicity mitigation

The IQGAP1-Claudin Cell Junction Axis in Cisplatin-induced Kidney Damage

This study investigates how cisplatin causes kidney damage by disrupting the IQGAP1-claudin cell junction axis, leading to epithelial cell dissociation and identifying potential therapeutic targets.

4-Methylpyrazole-mediated inhibition of Cytochrome P450 2E1 protects renal epithelial cells, but not bladder cancer cells, from cisplatin toxicity

This study shows that inhibiting CYP2E1 with 4MP protects kidneys from cisplatin toxicity but does not affect cisplatin's anti-cancer effects in bladder cancer cells.

Gynura procumbens Leaf Extract-Loaded Self-Microemulsifying Drug Delivery System Offers Enhanced Protective Effects in the Hepatorenal Organs of the Experimental Rats

This study develops a self-microemulsifying drug delivery system for Gynura procumbens leaf extract, showing improved hepatorenal protection in rats with liver and kidney injury.

Remote organ cancer adversely alters renal function and induces kidney injury, inflammation, and fibrosis.

This study shows that certain cancers alter kidney function and cause injury, inflammation, and fibrosis, independent of chemotherapy or metastasis.