Chemotherapy-induced organ toxicity mitigation

Naringenin Attenuates Cisplatin-Induced Hepatotoxicity and Nephrotoxicity by Restoring Glutathione Homeostasis and Suppressing Lipid Peroxidation in a Murine Model

This study shows naringenin reduces cisplatin-induced liver and kidney damage by improving glutathione levels and reducing lipid peroxidation in mice.

The IQGAP1-Claudin Cell Junction Axis in Cisplatin-induced Kidney Damage

This study investigates how cisplatin causes kidney damage by disrupting the IQGAP1-claudin cell junction axis, leading to epithelial cell dissociation and identifying potential therapeutic targets.

Protective Effects of Zingiber officinale Juice Extract Against Cisplatin-Induced Toxicity: Oxidative Stress, Biochemical, Hematological, And Reproductive Hormone Changes in Wistar Rats

This study evaluates the protective effects of Zingiber officinale juice against cisplatin-induced toxicity in rats, showing reduced oxidative stress, improved biochemical parameters, and inhibited apoptosis.

4-Methylpyrazole-mediated inhibition of Cytochrome P450 2E1 protects renal epithelial cells, but not bladder cancer cells, from cisplatin toxicity

This study shows that inhibiting CYP2E1 with 4MP protects kidneys from cisplatin toxicity but does not affect cisplatin's anti-cancer effects in bladder cancer cells.

Gynura procumbens Leaf Extract-Loaded Self-Microemulsifying Drug Delivery System Offers Enhanced Protective Effects in the Hepatorenal Organs of the Experimental Rats

This study develops a self-microemulsifying drug delivery system for Gynura procumbens leaf extract, showing improved hepatorenal protection in rats with liver and kidney injury.

Remote organ cancer adversely alters renal function and induces kidney injury, inflammation, and fibrosis.

This study shows that certain cancers alter kidney function and cause injury, inflammation, and fibrosis, independent of chemotherapy or metastasis.

The antioxidative effect of oligomeric procyanidins on neutrophil extracellular traps alleviate chemotherapy-induced chronic kidney injury via gut-kidney axis

This study shows that oligomeric procyanidins reduce chemotherapy-induced chronic kidney injury by inhibiting neutrophil extracellular traps through gut-kidney axis mechanisms.

Lcn2 protects from cisplatin induced AKI by regulating DNA damage response via EGFR activation

This study shows Lcn2 protects kidneys from cisplatin-induced AKI by activating the EGFR pathway to reduce apoptosis.

The exosomes derived from urine of premature infants target MAPK8 via miR-30a-5p to protect cisplatin-induced acute kidney injury in mice

This study shows that exosomes from premature infant urine reduce cisplatin-induced acute kidney injury in mice by delivering miR-30a-5p, which targets MAPK8 to prevent apoptosis.