Peptidase Inhibition and Analysis

Structural Basis for the Rational Design of UAMC-1110-Based FAP Radiopharmaceuticals

This study identifies a stable charge-anchored binding mode for FAP ligands, providing a framework for designing effective radiopharmaceuticals.

Discovery of an orally available potent ER aminopeptidase 1 (ERAP1) inhibitor that enhances anti-tumor responses and limits inflammatory autoimmunity in vivo.

FAP overexpression induce Epithelial-Mesenchymal Transition (EMT) in oral squamous cell carcinoma by down-regulating DPP9 gene.

This study shows FAP promotes EMT in OSCC by down-regulating DPP9, which accelerates proliferation and invasion.