Author

John Liddle

GlaxoSmithKline (United Kingdom)ORCID 0000-0003-1805-3728Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1 Organism:mouse· 1

Frequent Co-Authors

Alex Phillipou· 1 shared Ashley P. Hancock· 1 shared Bethan A. ColeiD· 1 shared Chloe L. TayleriD· 1 shared Christopher P. TinworthiD· 1 shared David F. ToughiD· 1 shared David J. HirstiD· 1 shared Despoina KoumantouiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperImmunology

Alex Phillipou

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

BiochemistrybioRxivPreprintJan 8, 2026

Structural mechanism of TRPC3 inhibition by a potent and selective antagonist

Jodie Collingridge, Bethan A. Cole, John Liddle…·Esther B E Becker

This study identifies a potent and selective TRPC3 inhibitor, GSK2820986A, and elucidates its binding mechanism through molecular dynamics and functional assays.

1 citation

mechanistic / dynamical modeldrug response / drug discovery

𝕏 PostBluesky

ImmunologybioRxivPreprintNov 17, 2025

Discovery of an orally available potent ER aminopeptidase 1 (ERAP1) inhibitor that enhances anti-tumor responses and limits inflammatory autoimmunity in vivo.

Christopher P. Tinworth, Justyna Wojno, Michael Adam…·Efstratios Stratikos

DOI 10.1101/2025.11.17.686761

mouseexperimental assay

𝕏 PostBluesky