Efstratios Stratikos

The paper investigates how ERAP1 allotypes 2 and 10 affect the immunopeptidome of melanoma cells, finding quantitative changes in peptide abundance rather than sequence differences.

This study shows that ERAP1 inhibition alters the immunopeptidome and proteome in cancer cells, affecting metabolism and stress responses, but only a small fraction of proteomic changes impact the immunopeptidome.

This study investigates the enzymatic properties of ERAP1 allotype 10, showing that polymorphisms V349M and Q725R significantly affect its activity, kinetics, and thermodynamics compared to allotype 1.

This paper identifies a nanomolar inhibitor of IRAP that stabilizes its open conformation, revealing a conformation-specific mechanism of action and insights into its catalytic cycle.