Brain-wide reconfiguration of burst firing by psilocybin reveals 5-HT2A-dependent circuit dynamics
Davide Momi, Yasmeen Nahas, David G Wyrick, Lydia C. Marks, Leslie D. Claar, Roberto De Filippo, Parsa Seyfourian, Diego A. Pizzagalli, Michael A. Buice, Torben Ott, Christof Koch A, Irene Rembado
In awake mice, psilocybin changed burst firing rather than mean firing rate across thalamus and hippocampus. Ketanserin pretreatment abolished most burst effects, but EEG power and firing-rate changes persisted.
bioRxiv · Sep 7, 2026 · PreprintNeuroscience✦ In-depth digest