Psychedelics and Drug Studies

Serotonergic psychedelics delay resting state neurovascular coupling dynamics

This study shows serotonergic psychedelics like LSD and DMT delay resting state neurovascular coupling, affecting hemodynamic delays and functional connectivity in brain regions with serotonin receptors.

Context Shapes Alpha-Band Electrophysiological Signatures Under Psilocybin

The paper examines how naturalistic context affects psilocybin's frequency-specific electrophysiological effects using EEG data from 56 participants.

Language-associated brain representations covary with disruption of selfhood under psilocybin

The paper uses fMRI to show that psilocybin increases similarity in language-associated brain activity, correlating with ego dissolution.

Serotonin2A receptors in the medial prefrontal cortex do not drive DOI-induced head-twitch responses in rodents

This study investigates the role of 5-HT2A receptors in the medial prefrontal cortex in DOI-induced head-twitch responses in rodents, finding no contribution from mPFC 5-HT2ARs.

Psychedelics restructure information in the human brain

This study uses multivariate information decomposition to analyze how five psychedelics alter information processing in the human brain, revealing new insights into neural reorganization.

Multimodal autonomic arousal tracks dose-dependent affective dynamics during the acute effects of DMT

This study tracks dose-dependent affective dynamics during DMT's acute effects using multimodal physiological signals and phenomenological reports.

Psychedelics Restructure the Global Workspace of Consciousness

This study investigates how psychoactive drugs alter the global workspace of consciousness by analyzing resting-state fMRI data, finding distinct changes in synergistic and redundant interactions across drug types.

Spiral brain dynamics track the temporal unfolding of subjective intensity during the N,N-dimethyltryptamine experience

This study introduces vorticity-based metrics to analyze brain dynamics during DMT experiences, finding increased rotational organization and spatial heterogeneity associated with subjective intensity changes.

Psychedelic Hormesis: LSD Activates Adaptive Stress Transcriptional Programs in the Prefrontal Cortex

This study shows LSD induces adaptive stress transcriptional programs in the prefrontal cortex of mice, aligning with hormetic adaptation rather than chronic stress.

Acute lysergic acid diethylamide induces a time-dependent shift toward hippocampal control of default mode network reorganization

This study examines how acute LSD affects brain connectivity in rats, showing a time-dependent shift in network control from cortical to hippocampal regions.

Brain-wide reconfiguration of burst firing by psilocybin reveals 5-HT2A-dependent circuit dynamics

In awake mice, psilocybin changed burst firing rather than mean firing rate across thalamus and hippocampus. Ketanserin pretreatment abolished most burst effects, but EEG power and firing-rate changes persisted.

A dominant frontoparietal beta oscillatory brain state in the days after psilocybin and 5-MeO-DMT

The paper identifies a dominant beta oscillatory brain state in the days after psilocybin or 5-MeO-DMT use using resting-state EEG and dynamic functional connectivity analysis.

Psilocybin collapses visual change detection and drives cortical dynamics toward a state of surprise

This study shows psilocybin disrupts visual change detection by altering cortical dynamics, particularly in SST interneurons, leading to increased surprise signals.

Appetite for change: How nutritional state and ventral striatal dopamine shape psilocybin effects on cognitive flexibility

This study shows psilocybin improves cognitive flexibility in rats under food restriction but not after anorexia exposure, with changes in striatal dopamine signaling.

Tuning in together: LSD enhances inter-brain synchrony and felt connectedness in romantic couples

This study shows that LSD increases inter-brain synchrony and felt connectedness in romantic couples during rest and interaction, independent of drug concentration.

Psilocybin lengthens hippocampal sharp wave ripples

This study examines how psilocybin affects hippocampal sharp wave ripples in rodents, finding reduced frequency and increased duration of these oscillations.

Sex Differences in Acute Responses to Psychedelics: Evidence for Greater Subjective Intensity and Impairment in Female Participants

This study finds that female participants report greater subjective intensity and impairment during acute psychedelic experiences compared to males, independent of drug exposure and age.

Psilocybin asymmetrically modulates outcome-based choice and cortical processing under uncertainty

This study shows psilocybin enhances choice selection in uncertain contexts by altering cortical processing to prioritize positive information over previous actions.

Preclinical Comparison of DMT and 5-MeO-DMT Reveals Behavioral Dissociation, Distinct TrkB Activation and Differential Plasticity Profiles

This study compares the acute pharmacology and long-term neuroplastic effects of DMT and 5-MeO-DMT in mice, showing distinct behavioral and molecular outcomes.

MDMA-Enhanced Exposure Therapy Reverses PTSD-Like Features In a Learned Helplessness Mouse Model

This study shows that MDMA combined with exposure therapy rapidly reduces PTSD-like behaviors in a mouse model, supporting its potential for more efficient PTSD treatment.

Investigating the Effects of Psilocybin on Cognitive Flexibility in Touchscreen and Naturalistic Variations of the Probabilistic Reversal Learning Task

This study examines the acute and post-acute effects of psilocybin and LSD on cognitive flexibility in rats using two probabilistic reversal learning tasks, finding no robust enhancement of reversal learning.

Temporal effects of a single oral dose of psilocybin on plasma circulating miRNAs in healthy young adults.

This study examines how a single psilocybin dose affects plasma miRNA levels in healthy adults, finding transient changes in specific miRNAs linked to neuroplasticity and inflammation.

Psilocybin acutely dissociates cognitive and affective empathy, with empathic concern predicting persisting positive psychological effects

This study examines how psilocybin affects different aspects of empathy and links empathic concern to long-term psychological benefits.

Circulating MicroRNAs and Their Associations with Neurotrophic, Inflammatory and Glutamate Markers in Healthy Volunteers

The paper examines associations between psilocybin-induced changes in circulating microRNAs and neurotrophic, inflammatory, and glutamatergic markers in healthy volunteers.

Multidimensional characterization of the physiological and behavioral effects of TCB-2 in mice

This study examines the effects of TCB-2 on multiple physiological and behavioral measures in mice, finding distinct effects across different metrics and partial modulation by a 5-HT2A antagonist.

Mapping excitatory synaptic plasticity evoked by single-dose psilocybin in mice

This study investigates how a single dose of psilocybin affects excitatory synaptic plasticity in mice, showing region-specific changes linked to serotonin receptor expression.

Mind-manifesting? Examining naturalistic reports from psychedelics, cannabis, meditation, and dreams from the ALTERD mobile application

The paper analyzes 2,242 naturalistic reports from the ALTERD app to compare the phenomenology of psychedelics, cannabis, meditation, and dreams, finding psychedelics align with dreams and meditation in some aspects but show unique transformative features.

Identifying factors that contribute to the behavioral effects of psilocybin in preclinical mouse models

The paper identifies biological and experimental factors influencing psilocybin's behavioral effects in mice using a large dataset and data-driven analyses.

The psychedelic DOI decreases the modularity of the cortical network by increasing cortico-cortical and thalamo-cortical functional influence

This study shows that the psychedelic DOI reduces cortical network modularity by increasing functional influence between cortical domains in mice.

Estimating Cardiac 5-HT2B Safety Margins for Repeated Low-Dose Psilocybin Using an Exposure-Response Model

This paper develops an exposure-response model to estimate cardiac safety margins for repeated low-dose psilocybin, finding a large safety margin due to psilocin's low-efficacy partial agonism and short half-life.