David G Wyrick

In awake mice, psilocybin changed burst firing rather than mean firing rate across thalamus and hippocampus. Ketanserin pretreatment abolished most burst effects, but EEG power and firing-rate changes persisted.

This study shows psilocybin disrupts visual change detection by altering cortical dynamics, particularly in SST interneurons, leading to increased surprise signals.

The paper shows that visual areas differentially encode temporal context and expectation in natural scenes, with representational drift observed in lower areas but not higher ones.

This study shows mice use monocular visual cues to judge distance during gap jumping, with visual cortex involvement, and demonstrates how sensory processing couples with motor output in a natural task.

This study shows freely-moving mice use sniff-synchronized nose movements to navigate odor gradients, identifying two distinct movement motifs during olfactory search.

The paper introduces a theoretical framework to predict how cell-type specific top-down perturbations affect cortical processing speed through intrinsic gain modulation, validated using electrophysiological recordings in mice.