Roberto De Filippo

Brain-wide reconfiguration of burst firing by psilocybin reveals 5-HT2A-dependent circuit dynamics

In awake mice, psilocybin changed burst firing rather than mean firing rate across thalamus and hippocampus. Ketanserin pretreatment abolished most burst effects, but EEG power and firing-rate changes persisted.

Psilocybin collapses visual change detection and drives cortical dynamics toward a state of surprise

This study shows psilocybin disrupts visual change detection by altering cortical dynamics, particularly in SST interneurons, leading to increased surprise signals.

Local inhibitory topology dictates the spatial compartmentalization of hippocampal sharp-wave ripples

The paper shows that inhibitory topology determines the spatial organization of hippocampal sharp-wave ripples, while inhibitory activity governs their dynamics.

Differential ripple propagation along the hippocampal longitudinal axis

The paper analyzes ripple propagation in the hippocampus using mouse recordings and finds that strong ripples originate from the septal pole and propagate differently based on their generation location.

Somatostatin interneurons activated by 5-HT2A receptor suppress slow oscillations in medial entorhinal cortex

The paper investigates how serotonin modulates slow oscillations in the entorhinal cortex and identifies somatostatin interneurons activated by 5-HT2A receptor as key suppressors of these oscillations in anesthetized mice.