Topic · Pharmacology · Pharmacology, Toxicology and Pharmaceutics
OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.
3 papers
Brent McNutt, Melissa R. L. Whitaker
The paper tests the herbivore defense hypothesis by showing kratom leaf and mitragynine affect insect growth and survival, but the effects are not mediated by mammalian opioid receptors.
bioRxiv · Jul 16, 2026 · PreprintEcology
Julio D. Zuarth Gonzalez, Alexandria K. Ragsdale, Sushobhan Mukhopadhyay, Christopher R. McCurdy, Lance Richard McMahon, Samuel Obeng, Jenny L. Wilkerson
This study examines the respiratory effects of mitragynine and 7-hydroxymitragynine in rats, finding that 7-HMG causes respiratory depression reversed by naloxone, while MG increases breathing independently of opioid receptors.
bioRxiv · May 16, 2025Pharmacology & Toxicology
Abhishek Gupta, Tuhin Bhattacharya, Subhamoy Pratihar, Sabnur Parvage, Swrajit Nath Sharma, Arnab Sarkar, Akash De, Sanmoy Karmakar, Sanjit Dey, Surajit Sinha
This paper develops bioisosteric iboga analogs with improved antinociceptive and anxiolytic properties and reduced cardiotoxicity compared to natural iboga alkaloids.
bioRxiv · Feb 24, 2025 · PreprintPhysiology