Topic · Molecular Biology · Biochemistry, Genetics and Molecular Biology

Advanced Biosensing Techniques and Applications

OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.

2 papers

Variability of 7K and 11K SomaScan plasma proteomics assays

Julián Candia, Giovanna Fantoni, Francheska Delgado‐Peraza, Nader Shehadeh, Toshiko Tanaka, Ruin Moaddel, Keenan A. Walker, Luigi Ferrucci

Across Baltimore Longitudinal Study of Aging replicates, fully normalized SomaScan 11K has median inter-plate coefficient of variation 5% (7K: 4.5%), intra-plate 3%, 7K inter-batch 8%.

Journal of Proteome Research · Oct 30, 2024Peer-reviewedSystems Biology✦ In-depth digest

Assessment of Variability in the Plasma 7k SomaScan Proteomics Assay

Julián Candia, Gulzar N. Daya, Toshiko Tanaka, Luigi Ferrucci, Keenan A. Walker

Using inter-plate duplicates from 102 donors, a self-contained normalization of the 7k SomaScan plasma assay yields median CV 4.5% across 7,288 human-protein SOMAmers.

Scientific Reports · Oct 13, 2022Peer-reviewedMolecular Biology✦ In-depth digest