Ruin Moaddel

Proteasome mutations associated with CANDLE syndrome cause altered neuronal development by dysregulating polyamine synthesis

This study shows that proteasome mutations in CANDLE syndrome disrupt neuronal development by increasing polyamine levels through ODC dysregulation, and inhibiting ODC can reverse these effects.

SomaModules: a pathway enrichment approach tailored to SomaScan data

This paper introduces SomaModules, a pathway enrichment approach for SomaScan data, showing improved enrichment compared to original gene sets in Alzheimer's Disease and mitochondrial pathway analyses.

Effects of in vitro hemolysis and repeated freeze-thaw cycles in protein abundance quantification using the SomaScan and Olink assays

This study evaluates how in vitro hemolysis and freeze-thaw cycles affect protein abundance measurements in SomaScan and Olink assays, identifying affected analytes and proposing quality control measures.

Variability of 7K and 11K SomaScan plasma proteomics assays

Across Baltimore Longitudinal Study of Aging replicates, fully normalized SomaScan 11K has median inter-plate coefficient of variation 5% (7K: 4.5%), intra-plate 3%, 7K inter-batch 8%.

Ketamine metabolism via hepatic CYP450 isoforms contributes to its sustained antidepressant actions.

The paper investigates how ketamine's metabolism via hepatic CYP450 enzymes affects its antidepressant effects, finding that (6)-HNKs mediate sustained antidepressant actions.

Experimenter sex modulates mouse biobehavioural and pharmacological responses

This study shows that the sex of human experimenters affects mouse behaviors, stress responses, and drug responses like ketamine, mediated by CRF neurons.

Chemogenetic ligands for translational neurotheranostics

The paper develops new DREADD agonists and a PET radiotracer for improved neuronal activity manipulation and noninvasive projection mapping in neurotheranostics.