Author

Nader Shehadeh

National Institutes of Health

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 3 Approach:statistical model· 3 Research Focus:benchmarking· 2 Research Focus:database / resource· 2 Organism:human· 2 Approach:benchmark study· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Francheska Delgado‐PerazaiD· 3 shared Giovanna FantoniiD· 3 shared Julián CandiaiD· 3 shared Luigi FerrucciiD· 3 shared Ruin MoaddeliD· 3 shared Keenan A. WalkeriD· 2 shared Toshiko TanakaiD· 2 shared Toshiko Tanaka· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 26 mutual co-author links

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3 shared papersBioinformatics

Francheska Delgado‐PerazaORCID

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Author profile →

3 papers

Recent·Most cited

SomaModules: a pathway enrichment approach tailored to SomaScan data

Julián Candia, Giovanna Fantoni, Francheska Delgado‐Peraza, Nader Shehadeh, Toshiko Tanaka, Ruin Moaddel, Keenan A. Walker, Luigi Ferrucci

This paper introduces SomaModules, a pathway enrichment approach for SomaScan data, showing improved enrichment compared to original gene sets in Alzheimer's Disease and mitochondrial pathway analyses.

Journal of Proteome Research · Aug 11, 2025Peer-reviewedBioinformatics

Effects of in vitro hemolysis and repeated freeze-thaw cycles in protein abundance quantification using the SomaScan and Olink assays

Julián Candia, Giovanna Fantoni, Ruin Moaddel, Francheska Delgado‐Peraza, Nader Shehadeh, Toshiko Tanaka, Luigi Ferrucci

This study evaluates how in vitro hemolysis and freeze-thaw cycles affect protein abundance measurements in SomaScan and Olink assays, identifying affected analytes and proposing quality control measures.

Journal of Proteome Research · Apr 18, 2025Peer-reviewedMolecular Biology

Variability of 7K and 11K SomaScan plasma proteomics assays

Julián Candia, Giovanna Fantoni, Francheska Delgado‐Peraza, Nader Shehadeh, Toshiko Tanaka, Ruin Moaddel, Keenan A. Walker, Luigi Ferrucci

Across Baltimore Longitudinal Study of Aging replicates, fully normalized SomaScan 11K has median inter-plate coefficient of variation 5% (7K: 4.5%), intra-plate 3%, 7K inter-batch 8%.

Journal of Proteome Research · Oct 30, 2024Peer-reviewedSystems Biology✦ In-depth digest