Francheska Delgado‐Peraza

This paper introduces SomaModules, a pathway enrichment approach for SomaScan data, showing improved enrichment compared to original gene sets in Alzheimer's Disease and mitochondrial pathway analyses.

This study evaluates how in vitro hemolysis and freeze-thaw cycles affect protein abundance measurements in SomaScan and Olink assays, identifying affected analytes and proposing quality control measures.

Across Baltimore Longitudinal Study of Aging replicates, fully normalized SomaScan 11K has median inter-plate coefficient of variation 5% (7K: 4.5%), intra-plate 3%, 7K inter-batch 8%.

The paper tests whether Alzheimer's disease patient-derived extracellular vesicles induce complement-mediated neurotoxicity in neurons.