Atherosclerosis and Cardiovascular Diseases

This study identifies Rev-erb-alpha as a repressor of vascular calcification by inhibiting osteogenic reprogramming of vascular smooth muscle cells in atherosclerosis.

This study shows that chronic PDGF signaling increases VSMC apoptosis in atherosclerotic plaques by promoting PI3K-dependent c-Myc expression and reducing Bcl-2, leading to plaque instability.

This study identifies a lung-to-aorta inflammatory program driven by influenza that exacerbates atherosclerosis through shared circadian and Hippo/YAP pathway suppression.

This paper shows that introducing the IL6RA Glu357Ala substitution in mice reduces atherosclerosis and AAA, similar to the human IL6RA Asp358Ala variant's protective effect.

This study investigates the role of LSR in macrophage lipid homeostasis and metabolic activity, finding reduced LSR expression and activity in M1 and foam cell macrophages.