Atherosclerosis and Cardiovascular Diseases

Rev-erb-alpha inhibits vascular calcification by repressing osteogenic reprogramming in atherosclerosis

This study identifies Rev-erb-alpha as a repressor of vascular calcification by inhibiting osteogenic reprogramming of vascular smooth muscle cells in atherosclerosis.

An Apoptotic Failsafe Program Involving PDGF-dependent PI 3-Kinase Activity Contributes to Plaque Composition in Atherosclerosis

This study shows that chronic PDGF signaling increases VSMC apoptosis in atherosclerotic plaques by promoting PI3K-dependent c-Myc expression and reducing Bcl-2, leading to plaque instability.

Genome-Wide Transcriptomics Uncovers a Lung-to-Aorta Inflammatory Program Driving Influenza-Induced Atherosclerosis Exacerbation

This study identifies a lung-to-aorta inflammatory program driven by influenza that exacerbates atherosclerosis through shared circadian and Hippo/YAP pathway suppression.

A rare pre-existing progenitor-like Primed SMC compartment is the dominant inferred source of SMC-derived cellularity in vascular injury and atherosclerosis

Sexually Dimorphic Transdifferentiation of Endothelial Cells in Atherosclerosis

This study identifies sex-specific endothelial cell transdifferentiation trajectories in atherosclerosis, revealing distinct fates in males and females and a novel direct EC-to-adipocyte transition.

Modelling the human IL6RA Asp358Ala variant in mice: effects on atherosclerosis and abdominal aortic aneurysm

This paper shows that introducing the IL6RA Glu357Ala substitution in mice reduces atherosclerosis and AAA, similar to the human IL6RA Asp358Ala variant's protective effect.

Role of the lipolysis stimulated lipoprotein receptor LSR in the regulation of macrophage lipid homeostasis and metabolic activity

This study investigates the role of LSR in macrophage lipid homeostasis and metabolic activity, finding reduced LSR expression and activity in M1 and foam cell macrophages.