Author

Stephan Rosenkranz

University Hospital CologneORCID 0000-0001-6237-1470Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Organism:rat· 1

Frequent Co-Authors

Anoop Vadakan Cherian· 1 shared Astrid WietelmanniD· 1 shared Chanil ValasarajaniD· 1 shared Eva Maria BerghauseniD· 1 shared Giovanni MaroliiD· 1 shared Golnaz Hesami· 1 shared Holger WinkelsiD· 1 shared Joachim HerziD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMolecular Biology

Anoop Vadakan Cherian

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2 papers

Recent·Most cited

An Apoptotic Failsafe Program Involving PDGF-dependent PI 3-Kinase Activity Contributes to Plaque Composition in Atherosclerosis

Marius Vantler, Eva Maria Berghausen, Moritz Schwab, Mario Zierden, Wolfram‐Hubertus Zimmermann, Norbert Gerdes, Michelle D. Tallquist, Joachim Herz, Holger Winkels, Stephan Ernst Baldus, Stephan Rosenkranz

This study shows that chronic PDGF signaling increases VSMC apoptosis in atherosclerotic plaques by promoting PI3K-dependent c-Myc expression and reducing Bcl-2, leading to plaque instability.

bioRxiv · Oct 28, 2026 · PreprintBiochemistry

Targeting ADORA-PDE10 cAMP Microdomain: A Novel Therapeutic Approach for Pulmonary Hypertension

Chanil Valasarajan, Golnaz Hesami, Giovanni Maroli, Anoop Vadakan Cherian, Julio Castro Palomino Laria, Nahomi Castro Palomino Laria, Astrid Wietelmann, Leoni Gnatzy-Feik, Stephan Rosenkranz, Rajkumar Savai, Werner Seeger, Soni Savai Pullamsetti

This study shows that targeting ADORA1 and PDE10A together improves PAH symptoms in animal models by increasing cAMP levels and reducing vascular remodeling.

bioRxiv · Oct 27, 2024 · PreprintMolecular Biology