Experimental reasoning in large language models
This study demonstrates that large language models can design, execute, and revise experiments autonomously using a robotic system.
363,000+ bioRxiv and medRxiv preprints, including those later published in peer-reviewed journals, across 26 biological disciplines.
This study demonstrates that large language models can design, execute, and revise experiments autonomously using a robotic system.
Meaghan C. Loud, Sarah L Broders, Qingxin Zheng…·Lonnie D. Shea
This study shows gonadal and chromosomal sex independently and together affect immune responses to implanted scaffolds in mice.
Joanie Lucas, J Alaina Floyd, Erin Hickey…·Gabriel C. Graffius
This paper describes the development of a low-volume, low-viscosity, once-every-4-weeks autoinjector for povetacicept, focusing on improving patient experience through formulation and device integration.
Kejia Wu, Tiana Schantz, Lemuel Chang…·David A. Baker
The paper designs and validates protein readers that specifically detect disease-related modifications in Tau and Abeta in Alzheimer's disease models and human samples.
Bhavya Jaiswal, Md Nazibul Islam, Zachary R. Gagnon
This paper introduces a low-cost, scalable microfluidic electroporation technique for bacterial transformation with improved cell viability and efficiency compared to traditional cuvette-based methods.
Flávia Souza Almeida, Mariangeles Paloma Zacarias, Samuel Olutunde Durosaro…·Meghan Barrett
This paper develops mathematical models to determine humane slaughter conditions for black soldier fly and yellow mealworm larvae using hot water immersion, finding optimal temperatures and time-to-death thresholds.
Jieyuan Tian, Shawnus Chen, Max Shotbolt…·Sakhrat Khizroev
This paper proposes a neuromodulation system using a conductive ring interface that generates a highly localized electric field with minimal magnetic field requirements.
Parsa Parvizian, Hossein Moghimianavval, Allen P. Liu
This study develops a cell-free biosensing reporter using rapalog-induced split sfCherry reconstitution and demonstrates steric attenuation of fluorescence by antibodies binding to epitope tags.
Krithika Swaminathan, Kirsten A. Seagers, Julie A. Kolesar…·Jennifer L. Hicks
This study evaluates OpenCap's accuracy in measuring ACL injury risk factors both in and out of the lab compared to optical motion capture.
Haeun Kang, Jeongmin Park, Hyung Joo Lee…·Luke P. Lee
This paper introduces a chirality-driven photonic PCR method that enables rapid, label-free genetic amplification by using chiral plasmonic nanoparticles to enhance photothermal conversion and DNA synthesis efficiency.
Harshan Ravi, Deborah R. Healey, Neha Damodar…·C. Chad Quarles
This study evaluates a dual-labeling protocol for mesenchymal stem cells with iron oxide particles and an oncolytic virus, showing preserved cellular function and MRI detectability.
Fatma Ceren Kırmızıtaş, Sudipta Mallick, Subrahmanyam Cherukumilli…·Sambeeta Das
This study compares microrobot and cellbot locomotion on synthetic substrates and cardiac tissue, showing how surface interactions and magnetic fields affect movement speed and direction.
Goldie V. Roth, Izzi Rose Gengaro, Negar Ahmadian…·Lei S. Qi
The paper introduces DARTs, a platform for programmable cell targeting using antibody-conjugated nanoparticles, identifying new surface antigens for gene editing in neural cells.
Shintaro Nakatani, W. Yang, Jennie Posen…·Minoru Shinohara
This study uses model-optimized transcutaneous vagus nerve stimulation to enhance visuomotor reaction during dark transitions by increasing pupil dilation and improving performance.
Michael J. Bennington, Stephen M. Rogers, Gregory P. Sutton…·Victoria A. Webster‐Wood
This study investigates how forces from bending structures scale with size and geometry, showing differences from spring-like structures and implications for biomechanics.
Lena Elliger, Tom van Hattem, Mariana Azevedo Gonzalez‐Oliva…·Miguel Dias Castilho
This paper introduces a 3D bioprinting technique called Mechanoscribed Xolography to create cell-laden hydrogels with controlled mechanical heterogeneity and monitors their evolution over time.
Zahed Tavangari, Ali Maghami, A. Papangelo, Giada Graziana Genchi
The paper develops a finite element-Gaussian process framework to rapidly predict optimal extrusion parameters for bioprinting skeletal myoblasts in alginate hydrogel, identifying conditions that minimize cell damage while maintaining flow rate.
Leili Soo, Eirini Schoinas, Geoffrey M. Boynton…·Eduardo Fernández
The paper models phosphenes elicited by intracortical stimulation in human V1, showing that electrode stimulation can produce varied shapes due to activation of multiple locations.
Pritam Kumar Patel, Bhushan J. Toley
The paper develops a workflow for spatially resolved gene expression analysis in a multilayer paper-based 3D tumor model, showing distinct spatial patterns and pharmacological responses.
Jake Song, Sarah Jones, Fan Yang…·Ovijit Chaudhuri
This study shows that chondrocytes respond to solid stress from their nascent matrix in hydrogels, leading to inflammatory and migratory responses associated with osteoarthritis.